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Oncology

GenePath Dx BCR-ABL IS RQ-PCR test kit

• Minimal Residual Disease determination through BCR-ABL/ABL ratio reported on the International Scale (IS)
• Single-pot duplex assay with integrated reverse transcription (RT) / cDNA synthesis and qPCR
• Wide dynamic range / high sensitivity providing accurate quantification of the Major BCR-ABL e13/e14-a2 (p210) and ABL transcripts
• Reactions incorporate the dUTP / UNG system which helps to minimise carry-over contamination
• Two channel assay with broad instrument compatibility (kit validated on the Qiagen Rotor-Gene Q, Bio-Rad CFX96, Bio-Rad Opus, Roche LightCycler II 480, Thermo/ABI QuantStudio5 and StepOne instruments; fluorophores compatible with most real time thermocyclers)
• Secure online tool to assist with data analysis

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GenePath Dx PML-RARA RQ-PCR test kit (RUO)

• Monitoring of Acute Promyelocytic Leukemia (APML) Minimal Residual Disease (MRD) through relative quantification of the PML-RARA fusion transcript
• Detects the common breakpoints of PML-RARA: (bcr2, V) (ex6a-ex3), (bcr1, L) (ex6b-ex3) and (bcr3, S) (ex3-ex3)
• Single-pot duplex assay with integrated reverse transcription (RT) / cDNA synthesis and qPCR
• Wide dynamic range / high sensitivity providing accurate quantification of the PML-RARA and ABL transcripts
• Reactions incorporate the dUTP / UNG system which helps to minimise carry-over contamination
• Two channel assay with broad instrument compatibility (kit validated on the Qiagen Rotor-Gene Q, Bio-Rad CFX96, Bio-Rad Opus, Roche LightCycler II 480, Thermo/ABI QuantStudio5 and StepOne instruments; fluorophores compatible with most real time thermocyclers)
• Secure online tool to assist with data analysis

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